About the Project
This project will build on ongoing work in the Race laboratory in attempting to assemble from first principles a series of ‘designer’ biosynthetic assembly lines with the capacity to produce novel antibiotic compounds for clinical use. The project will combine molecular biology, protein biochemistry, synthetic biology, biomolecular engineering and analytical chemistry, and will involve significant collaboration with chemists and biologists in Bristol and thought the UK and Europe.
2) Maschio L, Parnell AE, Stach JE, Willis CL, Schaffitzel C, Race PR (2019) Cloning, Expression and Purification of Intact Polyketide Synthase Modules. Methods in Enzymol. 617: 63-82.
3) Wang L, Parnell AE, Williams C, Bakar N, Challand MR, van der Kamp MW, Simpson TJ, Race PR, Crump MP, Willis CL. (2018) A Rieske oxygenase/epoxide hydrolase cascade creates oxygen heterocycles in antibiotic biosynthesis. Nature Catalysis. 1: 968-976.
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