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Blending Synthetic Biology and Synthetic Chemistry for Catalytic C-H Activation and Diversification


   School of Chemistry

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  Prof Rebecca Goss  No more applications being accepted  Competition Funded PhD Project (Students Worldwide)

About the Project

This PhD Studentship Provides the Opportunity to Blend Synthetic Chemistry with Synthetic Biology.

The project is linked to our pioneering and multi- award winning work in using enzymatic C-Cl/C-Br/C-I bond formation in complement with synthetic technologies for precision molecule editing.

A key challenge in drug discovery is the ability to carry out late-stage functionalisation and diversification, especially when this involves C-H activation. Such functionalisation holds the key to activity and bioavailability tuning. Enzymatic halogenation opens a door to selective C-H activation and diversification. The combination of enzymatic halogenation and chemical diversification was first exemplified in 2010 (JACS).2 Since then the Goss group have demonstrated the ability to mine and harness novel halogenases with capability of late stage functionalisation of complex and pharmaceutical relevant molecules. This studentship will work toward establishing enzymatic, chemical and synthetic biological tools for late stage diversification and functionalisation, and will lean on AI approaches to expedite discovery.

We seek a talented, creative individual to join the Goss Group. You will be a careful and able experimentalist with experience in either synthetic organic chemistry or protein biochemistry. The successful applicant will be passionate about sustainable chemistries and enzymology, energetic, well organised, and an excellent communicator and team player.

https://rjmg.wp.st-andrews.ac.uk

Twitter @GossGroup

LinkedIn: https://www.linkedin.com/in/professor-rebecca-goss-frsc-frse/

HOW TO APPLY

Application instructions can be found on the EASTBIO website: http://www.eastscotbiodtp.ac.uk/how-apply-0

1)     Download and complete the Equality, Diversity and Inclusion survey.

2)     Download and complete the EASTBIO Application Form.

3)     Submit an application to St Andrews University through the Online Application Portal

Your online application must include the following documents:

-         Completed EASTBIO application form

-         2 References (to be completed on the EASTBIO Reference Form, also found on the EASTBIO website)

-         Academic Qualifications

-         English Language Qualification (if applicable)

Unfortunately due to workload constraints, we cannot consider incomplete applications. Please make sure your application is complete by Monday 5th December 2022.

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Please also see: https://www.st-andrews.ac.uk/chemistry/prospective/pgr/ for the application procedure or e-mail [Email Address Removed] for more information regarding other PhD opportunities at St Andrews. We encourage applications for the EaSiCAT Centre for Doctoral training (http://www.criticat.co.uk) and from Chinese nationals through the St Andrews CSC Scheme (https://csc.wp.st-andrews.ac.uk/). There are opportunities for self-funded PhD students to make use of the St Andrews Handsel Scheme to fund the difference between home and international fees.


Funding Notes

Full funding available for successful applicants to this EASTBIO Competition funded studentship.
This 4 year PhD project is part of a competition funded by EASTBIO BBSRC Doctoral Training Partnership.
This opportunity is open to UK and International students and provides funding to cover stipend at UKRI standard rate and UK level tuition fees.

References

Nature Chemistry, 2019, 1091-1097 DOI: 10.1038/s41557-019-0349-z
Nature Commun. 2017, 8, 229. DOI: 10.1038/s41467-017-00194-3.

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