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Bone morphogenetic protein signalling in vascular diseases - BMP9/10 non-Smad signalling pathways: new targets for HHT treatment?

  • Full or part time
  • Application Deadline
    Wednesday, May 01, 2019
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

Project Description

The BMP in Angiogenesis and Lymphangiogenesis lab (BAL), part of the Interdisciplinary Research Institute of Grenoble (IRIG), aims to better understand the involvement of the Bone morphogenetic protein signalling pathway in vascular development and vascular diseases. The lab generates cellular and animal models to further dissect disease processes and test new therapies. It collaborates closely with state-of-the art technological platforms based at the CEA and clinicians to provide viable and tangible knowledge-based improvements in health-care.
http://www.bci-lab.fr/en/Pages/BAL/Presentation.aspx

For the EU-MSCA-ETN project V.A. Cure, the lab invites applications for an Early Stage Researcher/PhD student position (ESR13). You will be part of a team of 14 ESRs working on the V.A. Cure project, which aims to uncover core mechanisms of initiation and maintenance of Vascular Anomalies with the final goal to establish novel therapeutic strategies. The project is funded in the frame of the EU MSCA-ITN programme.

Job description

You will work on a research project with the following objectives:
• Study the non-Smad signalling pathways in response to BMP9 and BMP10 (Proteomic, ChSeq)
• Study the crosstalk of BMP9/10 signalling with other vascular pathways (VEGF/Angiopoietin), flow, mechanotransduction
• Identify and test new therapeutic targets for vascular diseases, drug repurposing (high-through put sreening)
• Develop in vivo models for HHT to test new therapies
You will also take part in the international training programme of the network and participate in various networking and outreach events.

Requirements

We are looking for a motivated student with a strong commitment to basic and/or translational research, who:
• is eligible for MSCA-ETN funding, see Funding Notes.
• has a MSc degree in biology, physiology, biomedical sciences or related disciplines
• is a team player with good communication skills

Appointment terms

The successful candidate will receive an attractive salary in accordance with MSCA regulations for Early Stage Researchers. The period of employment is 3 years. Starting date: June – October 2019.

How to apply

– Make sure you meet the qualifying requirements.
– Submit your application to by e-mail, mentioning ‘application for ESR13’ in the subject line. Please send one pdf file containing:
• A motivation letter describing your research career goals, skills and experience (cover letter)
• Curriculum vitae
• Grade transcripts and BSc/MSc diploma (in English or with a translation into English)
• Two letters of recommendation or the contact information for at least 2 referees.

Deadline for submitting applications: 1 May 2019

More information

Please visit http://www.vacure.eu for more information on the project, the recruitment and selection criteria. Contact for questions:

Funding Notes

To be eligible for this H2020-MSCA-ITN funded PhD student position, you must:
– not have resided or carried out your main activity (work, studies, etc.) in the country of the recruiting beneficiary for more than 12 months in the 3 years immediately before the recruitment date. Compulsory national service, short stays such as holidays, and time spent as part of a procedure for obtaining refugee status under the Geneva Convention are not taken into account, and
– At the date of recruitment (=first day of employment), be in the first four years (full-time equivalent research experience) of your research career and not have been awarded a doctoral degree.

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