Department of Cellular Neurophysiology: http://www.iem.cas.cz/en/research/departments/department-of-cellular-neurophysiology/
The activation of glia as a reaction to brain tissue damage during ischemia or epileptic seizure results in an overexpression of extracellular matrix (ECM) molecules; these accumulate in the extracellular space and, together with the morphological changes of glial cells, affect its diffusion properties and thus extrasynaptic transmission. The presence of an aberrant ECM may not only lead to changes in the volume and tortuosity of the extracellular space, but may also shape post-ischemic tissue regeneration and/or epileptogenesis through the complex interplay between the ECM, astrocytes, and neurons; this could be an important factor in pathogenic plasticity. To evaluate the quantitative/qualitative ECM changes and the role of the distinct types of glial cells in post-ischemic and epileptic tissue with regards to brain diffusion, laboratory techniques, such as the real-time iontophoretic method, imunofluorescence, Western blot, fluorescence-activated cell sorting and RNA-Seq analysis, will be utilized in experimental animal models of transient ischemia and epilepsy.
A successful candidate should:
- have a master's degree in a biological, medical, or related field
- have a good working knowledge of English language
- be willing to work with laboratory animals (mice)
- be interested in learning new laboratory techniques
- be able to work independently as well as in a team
How to apply: www.iem.cas.cz/phd
If you are interested, please visit the official website and submit the simple online application form. You can apply for up to 3 PhD positions. We are looking forward to hearing from you!
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