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Brain diffusion parameters and extracellular matrix changes in chronic post-ischemic and epileptic tissue


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Dr Lydia Vargova No more applications being accepted Funded PhD Project (Students Worldwide)
Prague Czech Republic Cell Biology Neuroscience Physiology

About the Project

Department of Cellular Neurophysiology: http://www.iem.cas.cz/en/research/departments/department-of-cellular-neurophysiology/

The activation of glia as a reaction to brain tissue damage during ischemia or epileptic seizure results in an overexpression of extracellular matrix (ECM) molecules; these accumulate in the extracellular space and, together with the morphological changes of glial cells, affect its diffusion properties and thus extrasynaptic transmission. The presence of an aberrant ECM may not only lead to changes in the volume and tortuosity of the extracellular space, but may also shape post-ischemic tissue regeneration and/or epileptogenesis through the complex interplay between the ECM, astrocytes, and neurons; this could be an important factor in pathogenic plasticity. To evaluate the quantitative/qualitative ECM changes and the role of the distinct types of glial cells in post-ischemic and epileptic tissue with regards to brain diffusion, laboratory techniques, such as the real-time iontophoretic method, imunofluorescence, Western blot, fluorescence-activated cell sorting and RNA-Seq analysis, will be utilized in experimental animal models of transient ischemia and epilepsy.

A successful candidate should:

- have a master's degree in a biological, medical, or related field

- have a good working knowledge of English language

- be willing to work with laboratory animals (mice)

- be interested in learning new laboratory techniques

- be able to work independently as well as in a team

How to apply: www.iem.cas.cz/phd

If you are interested, please visit the official website and submit the simple online application form. You can apply for up to 3 PhD positions. We are looking forward to hearing from you!


Funding Notes

After admission to the graduate program, the student usually receives an academic fellowship. In addition, the student becomes an IEM CAS employee and receives a salary (including payments towards social and healthcare insurance) and other benefits. This is financed by internal and grant funds of the IEM CAS.

References

Anderova et al.: Cell death/proliferation and alterations in glial morphology contribute to changes in diffusivity in the rat hippocampus after hypoxia-ischemia. J. Cereb. Blood Flow Metab. 31(3):894-907, 2011. doi: 10.1038/jcbfm.2010.168.
Zamecnik et al.: The extracellular matrix and diffusion barriers in focal cortical dysplasias. Eur J Neurosci. 36(1): 2017-2024, 2012. doi: 10.1111/j.1460-9568.2012.08107.x
Vargova and Sykova: Astrocytes and extracellular matrix in extrasynaptic volume transmission. Philos Trans R Soc Lond B Biol Sci. 369(1654):20130608, 2014. doi: 10.1098/rstb.2013.0608.


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