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Can Solid-State NMR Help Shed Light on Pharmaceutical Solid State Stability?

Department of Physics

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Prof S P Brown No more applications being accepted Funded PhD Project (European/UK Students Only)

About the Project

This is an EPSRC iCASE award in partnership with Pfizer.

During the development of novel therapies, analytical scientists spend some considerable time determining the shelf-life of products using lengthy stability studies. Enabling earlier final formulation selection based on an improved understanding of the causes of product
instability is the focus of this project. The use of multinuclear (1H, 13C, 19F and 31P) solid-state NMR techniques to probe the chemical and physical environment of active ingredients in solid state formulation matrices will be evaluated and the effects of varying the
manufacturing process on the active ingredient: non-active ingredient interface will be explored and correlated with product stability. This project aligns with EPSRC’s Healthcare Technologies theme and the ‘Developing Future Therapies’ area.

Solid-state NMR experiments will be performed in the Magnetic Resonance group, which is one of the best-equipped centres worldwide, with fast magic-angle spinning (MAS) probes (60+ or 100+ kHz) available at 500, 600 and 700MHz. In addition, you will also be able to apply to carry out experiments at the Warwick-hosted UK 850 MHz Solid-State NMR Facility.

For further information concerning the Warwick NMR group, see:

Informal enquiries about this project studentship can be made to Prof. Steven Brown at [Email Address Removed]

Funding Notes

A full 4 year studentship for UK or EU students (fees and maintenance) is available. Candidates should hold or expect to hold a 1st (or high 2.1) in Physics, Chemistry, or a related subject area.

The Physics department is proud to be an IOP Juno Champion and a winner of an Athena Swan Silver Award, reflecting our commitment to equal opportunity and to fostering an environment in which all can excel.
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