Broad Project Summary: Cancer is a leading cause of morbidity and mortality worldwide. Epigenetic changes are now recognised as a hallmark feature of cancer, but our understanding of factors that are responsible for tumour spread still remains limited. Epigenetic alterations such as DNA methylation (modifications in DNA structure that can alter gene expression without changing the actual genetic sequence) are dynamic in nature and have been implicated in every type of cancer. Understanding the role of these epigenetic changes in driving tumour development and identifying them early holds tremendous potential to understand cancer and will contribute to better outcome for patients. Recent studies have shown that tumour-specific methylation changes enable early detection of cancer with high sensitivity and specificity. We have projects that will involve studying epigenetic changes in colorectal, prostate and lung cancers. This PhD project will be based on bioinformatic and molecular analysis of cancer patients (from early stage or resistant to treatment) and model systems. The experimental work will involve preparation of next generation sequencing libraries, DNA methylation analysis, large analysis of epigenomic patient data, a range of molecular and cellular techniques and data analysis/bioinformatics. You will be working with an interdisciplinary team (including clinicians), gaining valuable experience.
The successful candidate will have obtained an eligible bachelor’s degree [(ie, BSc(Hons)/BBioMedSci(Hons)] or MSc with high academic excellence. Knowledge of the following areas would be desirable: bioinformatics, genetics/epigenetics and molecular biology. Please apply with your CV (including contact detail of three references), transcripts for academic qualifications and any other relevant information in regards to your application, in a single PDF. The project comes with working expenses, consumables and training opportunities required for a PhD, but does not include a student scholarship. You will be required to apply for a PhD scholarship (which we will assist to the successful candidates) and therefore excellent academic record is necessary.
For further information please contact Associate Professor Aniruddha Chatterjee. Expressions of interest are welcome now.
Please apply with your CV (including contact detail of three references), transcripts for academic qualifications and any other relevant information in regards to your application, in a single PDF.
Learn more about our lab
Promo video: https://youtu.be/spK3BFezedw
Lab website: https://www.otago.ac.nz/chatterjee-lab/index.html