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Cancer evolution: Genomics of the asbestos-related cancer mesothelioma

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Cancer genome sequences show that cancer is a highly heterogeneous disease, with each patient having a unique mutational profile. Reconstructing the evolutionary history of a tumour from multiregionallly-sampled data allows understanding of this heterogeneity, and is an exciting, rapidly-expanding research area. An example of this approach is identifying mutations that occurred early in the tumour’s history – truncal mutations – to enrich the mutation catalogue for potential driver mutations critical to tumour formation.

As part of the multidisciplinary Mesothelioma Research Programme at the University of Leicester http://www.mesothelioma-research-leicester.com/, we are recruiting patients and sampling multiple regions of their tumours.

This project will focus on the extensive copy number heterogeneity of mesothelioma, and its implications for the history of the tumour, prognosis and therapy. It can be developed along bioinformatic approaches, analysing data in an evolutionary context to analyse the nature and extent of copy number variation, or along more experimental biological approaches, using new long-read sequencing technologies to characterise genomic structural rearrangements in detail and to identify potential therapeutic targets,


References

Nat Rev Cancer. 2017 Jul 25;17(8):475-488

How good is research at University of Leicester in Biological Sciences?

FTE Category A staff submitted: 37.40

Research output data provided by the Research Excellence Framework (REF)

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