Dr S Martin
No more applications being accepted
Competition Funded PhD Project (European/UK Students Only)
About the Project
We are now accepting applications for our Cancer Research UK funded Clinical Research Fellowships to start in September 2019.
Our Cancer Research UK funded Clinical Research Fellowship provide up to 3 years’ support for clinically qualified professional to undertake research training within Barts Cancer Institute.
This training programme, part of a multi-million pound award from CRUK, aims to develop a cohort of medically qualified scientists equipped both intellectually and technically to conduct the highest quality research on cancer.
The scheme is designed to accommodate the dual clinical-research training career path by allowing fellows to spend a portion of their time on NHS sessions
Fellows will be appointed as a Clinical Research Fellow with the Institute and will be required to register for a PhD, based on research undertaken during the fellowship.
Project Outline:
Endometrial cancer is the 4th most common cancer in women and the most common gynaecological malignancy in the developed world. Although approximately 75% of patients present with early stage disease, 15-20% of these tumours recur after primary surgery. Outcomes for women with advanced or recurrent disease are extremely poor and the median survival in metastatic disease is only 7-12 months. Loss of the DNA mismatch repair pathway (MMR) is estimated to occur in approximately 30% of endometrial tumours and is associated with well-established poor prognostic indicators in many studies of endometrioid endometrial cancer, including high tumour grade, lymph node involvement, metastasis and recurrence. Our preliminary data suggest that this may be due to a deregulated mitochondrial metabolism. In this clinical research fellowship, using primary endometrial cells and a unique, extensive clinically annotated FFPE tumour collection from 570 endometrial cancer patients, we will determine whether dysfunctional mitochondrial metabolism is driving invasive disease in MMR-deficient endometrial cancer and ultimately provide a targetable approach for the treatment of MMR-mediated EC metastasis.
For more information, including entry requirements and how to apply, please see:
https://www.bci.qmul.ac.uk/en/study-with-us/postgraduate-research/cruk-clinical-research-fellowships-2019-20
Funding Notes
The fellowship include the following funding for 3 years:
- A salary commensurate with your current experience. This will be paid on the clinical academic scale + London weighting.
- Tuition fees at the home/EU rate
- Project consumables
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