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Despite significant advancements in cardiac research, heart disease remains a leading cause of mortality globally. Unexpected cardiac events can occur even in young, fit individuals engaged in routine activities. One promising avenue of research involves the use of induced pluripotent stem cells (iPSCs) to produce differentiated cardiac cells to replace damaged heart tissue. However, there are still many unknowns regarding the behaviour and connectivity of these cells in vitro.
This project aims to culture cardiac myocytes from iPSCs and develop computer models to simulate their activity and interconnections. The ultimate goal is to use the in silico model to elucidate the limitations of the in vitro stem cell model and identify specific pathways to improvement.
The project will be divided into three phases:
Phase I
Phase II
Phase III
We are seeking a student with some scripting experience (Python preferred) to conduct these studies. A background in cellular physiology, biochemistry, molecular biology, or pharmacology would be advantageous. This project offers a unique opportunity to contribute to our understanding of cardiac stem cell networks and their potential therapeutic applications.
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