This project is the first study to investigate functional food with high content of odd-chain fatty acids in the prevention of cardiovascular disease. Novel findings from this project will lend support to the food industry to develop products rich in odd-chain fatty acids for the prevention and treatment of cardiovascular disease.
Perturbation of lipid metabolism is closely associated with the development of metabolic disease. Human cohort studies have demonstrated the important biological significance of odd-chain fatty acids in human diseases. For instance, odd-chain fatty acids, C17:0 and C15:0, have been shown to reduce the risk of multiple sclerosis via increase the fluidity of membranes to a similar degree as polyunsaturated fatty acids. However, the effect of odd-chain fatty acids on cardiovascular diseases (CVD) is unclear.
Objective and Specific Aims: The overarching goal of this project is to define the extracellular vesicle (EV)-associated non-coding RNAs induced by odd chain fatty acids as key determinants on the metabolic remodelling of cardiomyocyte and arterial endothelial cell and explore the therapeutic potential of odd-chain fatty acids on CVD.
Aim-1: Determine the effect of odd-chain fatty acids on mitochondrial integrity and fatty acids -oxidation in human cardiomyocyte and vascular endothelial cell.
Aim-2: Define non-coding RNA profile associated with the secreted EVs from the odd-chain fatty acids (C15:0 and C17:0) treated cardiomyocyte and arterial endothelial cell in metabolic remodelling.
Aim-3: Explore the therapeutic potential of odd-chain fatty acids in animal models of CVD via the mediation of non-coding RNAs.
Significance: Novel findings from this project will lend support to the dairy industry to produce dairy products fortified with odd-chain fatty acids which may benefit the prevention and treatment of CVD.
Start Date: October 2022
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