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CAST: Active Monitoring of Cancer As An Alternative To Surgery – project 1


Department of Molecular and Clinical Cancer Medicine

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Prof M Pritchard , Prof AS Myint No more applications being accepted Funded PhD Project (European/UK Students Only)

About the Project

CAST (www.cast-cancer.eu) is a Marie Skłodowska Curie Innovative Training Network (ITN) funded by the European Commission. An advert for these posts is also available on the EU website (please see https://euraxess.ec.europa.eu/jobs/454880 (positions ESR 8 and 9) and https://cast-cancer.eu/EU_Projects/CAST.nsf)

The ITN involves a consortium of 13 high-profile research, industry, charity and medical organisations across several EU countries as well as 10 partner organisations and is coordinated by Leiden University Medical Centre. A total of 15 PhD students will be employed to work in this project, of which 2 will be recruited by the University of Liverpool.

The University of Liverpool’s main role in this project involves studying the role of radiotherapy and in particular contact x-ray brachytherapy (Papillon) in the treatment of rectal cancer.

This job opening covers two 3-year research positions in the frame of a 3-year PhD doctoral programme, resulting in a PhD degree awarded by The University of Liverpool. The doctoral research will include research secondments hosted by CAST partners. Your PhD will be supervised by Prof Mark Pritchard and Prof Arthur Sun Myint. All partners and their roles in the project are described in https://www.cast-cancer.eu

This first project is most suited to a person who has a medical qualification and is pursuing a career in a discipline involved in treating patients with rectal cancer (e.g. radiation oncology, medical oncology, colorectal surgery, gastroenterology). You will perform analyses of existing databases of more than 2500 rectal cancer patients who have been treated with contact x-ray brachytherapy (Papillon) at Clattrerbridge Cancer Centre by Professor Arthur Sun Myint over the last 27 years. This is the world’s largest cohort of patients treated by Papillon therapy. As well as patient outcomes there is also potential to assess treatment toxicity, quality of life and possibly health economics using existing datasets. In addition you will be involved in prospective studies involving rectal cancer patients receiving Papillon therapy. These will involve acquiring ethical approval and administering questionnaires and collecting/analysing patient derived biological samples to investigate potential biomarkers of response.

Qualifications and Experience
You should have a medical qualification and ideally some post qualification clinical experience, but should not already have a PhD. You should not have resided in the UK for more than 12 months in the 3 years prior to the recruitment date.
*Please note the English Language Requirement for EU Students is an IELTS score of 6.5 with no band score lower than 5.5.

As an essential criterion of the award, you should not have resided in the UK for more than 12 months in the 3 years prior to the recruitment date.

For further information please visit: https://my.corehr.com/pls/ulivrecruit/erq_jobspec_version_4.display_form?p_company=1&p_internal_external=E&p_display_in_irish=N&p_process_type=&p_applicant_no=&p_form_profile_detail=&p_display_apply_ind=Y&p_refresh_search=Y&p_recruitment_id=021390

To apply please send a CV, letter of interest and the details of academic referees to [Email Address Removed]

For application enquires please contact Prof Mark Pritchard on 0151 794 5772 email: [Email Address Removed]

Funding Notes

In view of the nature of these EU funded positions the successful applicants will be appointed as predoctoral research associates rather than as PhD students (salary scale £41,060.16 - £45,347.40 per annum). Tuition fees and laboratory bench fees are also included within the grant and will not need to be covered by the student. The salary is available for 3 years and the student will then an additional year (unfunded) in which to submit a PhD thesis.

References

1. Role of radiotherapy in the treatment of rectal cancer in older patients. Myint AS, Gérard JP.Eur J Surg Oncol. 2020 46(3):349-357.
2. Dose Escalation Using Contact X-ray Brachytherapy after External Beam Radiotherapy as Nonsurgical Treatment Option for Rectal Cancer: Outcomes From a Single-Center Experience. Sun Myint A, Smith FM, Gollins S, Wong H, Rao C, Whitmarsh K, Sripadam R, Rooney P, Hershman M, Pritchard DM. Int J Radiat Oncol Biol Phys. 2018;100(3):565-573.
3. Dose escalation using contact X-ray brachytherapy (Papillon) for rectal cancer: does it improve the chance of organ preservation? Sun Myint A, Smith FM, Gollins SW, Wong H, Rao C, Whitmarsh K, Sripadam R, Rooney P, Hershman MJ, Fekete Z, Perkins K, Pritchard DM. Br J Radiol. 2017; 90(1080):20170175.
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