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Cell biology of influenza A virus infections: Mechanistic research at the interface of virus entry and host proteins and processes.


   School of Cellular and Molecular Medicine


About the Project

Viruses are obligatory parasites that hijack cellular functions to survive. Virus entry - the steps before viral replication begins -is regulated by multitude of host proteins and processes that interact with the incoming virus. By speaking the language of the cell, viruses are able to manipulate the cell's proteins to promote viral entry and hence establish infection. The PhD project focusses on cellular genes that our group has selected from established RNAi screen and will follows them up for mechanistic insights.

Experience of cell and molecular biology is highly advantageous for the candidate. Virology experience is not essential but a strong interest in cellular biology is required.

Keywords: Cell Biology, Imaging, Virology, Virus-Host interactions.


References

Daly JL, Simonetti B, Klein K, Chen KE, Williamson MK, Antón-Plágaro C, Shoemark DK, Simón-Gracia L, Bauer M, Hollandi R, Greber UF, Horvath P, Sessions RB, Helenius A, Hiscox JA, Teesalu T, Matthews DA, Davidson AD, Collins BM, Cullen PJ, Yamauchi Y. Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science. 2020 Nov 13;370(6518):861-865. doi: 10.1126/science.abd3072. Epub 2020 Oct 20. PMID: 33082294.

Miyake Y, Keusch JJ, Decamps L, Ho-Xuan H, Iketani S, Gut H, Kutay U, Helenius A, Yamauchi Y. Influenza virus uses transportin 1 for vRNP debundling during cell entry. Nat Microbiol. 2019 Apr;4(4):578-586. doi: 10.1038/s41564-018-0332-2. Epub 2019 Jan 28. PMID: 30692667.

Banerjee I, Miyake Y, Nobs SP, Schneider C, Horvath P, Kopf M, Matthias P, Helenius A, Yamauchi Y. Influenza A virus uses the aggresome processing machinery for host cell entry. Science. 2014 Oct 24;346(6208):473-7. doi: 10.1126/science.1257037. PMID: 25342804.

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