Dr M Sherratt
Dr A P Gilmore
Dr Matiss Ozols
No more applications being accepted
Funded PhD Project (European/UK Students Only)
In many tissues damage to the extracellular matrix (ECM) can accumulate over a lifetime resulting in diseases such as arteriosclerosis, emphysema and arthritis. In skin, age-related changes in the dermal ECM are associated with increased fragility, stiffness and the external signs of ageing. There is compelling evidence that some ECM-derived peptides (matrikines) can promote the synthesis of new matrix proteins although the mechanisms of matrikine action are poorly understood. This PhD project aims to better characterise, and hence predict, the action of ECM-derived peptides on skin cells (in vitro and in vivo) in order to identify naturally occurring peptides which promote tissue repair. The student will become well versed in extracellular matrix biology, cell-matrix signalling, inflammation, the application of proteomic and transcriptomic technologies and the ethical and practical aspects of recruiting human volunteers in a clinical setting. The studentship is sponsored by Walgreens Boots Alliance and hence there will be ample opportunities for the student to be exposed to the commercial realities of product development and marketing within a large, multi-national commercial environment.
Applicants are expected to hold, or about to obtain, a minimum upper second class undergraduate degree (or equivalent) in cell biology, physiology, biochemistry or bioengineering. A Master’s degree in a relevant subject and/or experience in skin biology/ageing are desirable.
For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/).On the application form select PhD Cell Matrix Research.
Fully funded Studentship through Walgreens Boots Alliance. Studentship funding is for a duration of four years to commence in September 2019 and covers UK/EU tuition fees and an annual minimum stipend (£15,466 per annum 2019/20). Due to funding restrictions the studentship is open to UK and EU nationals only.
As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.
Eckersley A, Mellody KT, Pilkington S, Griffiths CEM, Watson REB, O’Cualain R, Baldock C, Knight D, Sherratt MJ. 2018. Structural and compositional diversity of fibrillin microfibrils in human tissues. J. Biol. Chem. 89:109-117.
Bradley EJ, Griffiths CEM, Sherratt MJ, Bell M, Watson REB. 2015. Over-the-counter anti-ageing topical agents and their ability to protect and repair photoaged skin. Maturitas. 80:265-272.
Wells JM, Gagger A, Blalock JE. 2015. MMP generated matrikines. Matrix Biology,. 44-46:122-129.
Duca L, Floquet N, Alix, AJP, Haye B, Haye B, Debelle L. 2004. Elastin as a matrikine. Critical Reviews in Oncology Haematology. 49:235-244.
Naylor EC, Watson RE, Sherratt MJ (2011). Molecular aspects of skin ageing. Maturitas. 69:249-256.