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Cell models to investigate mechanisms of disease; the role of redox in neurodevelopment and neurodegeneration


   School of Sport, Exercise and Rehabilitation Sciences

   Applications accepted all year round  Self-Funded PhD Students Only

About the Project

We use cell models of neurodevelopment and neurodegeneration to study the mechanisms that underpin diseases like schizophrenia and dementia. We are specifically interested in redox status and neuroinflammation in the progression of disease. This project would run along side work investigating the factors that perturb the amyloid processing pathway, and work investigating the role of neuroinflammation in neurodevelopment.


References

Elsworthy RJ, King MC, Grainger A, Fisher E, Crowe JA, Alqattan S, Ludlam A, Hill DEJ, Aldred S. Amyloid-β precursor protein processing and oxidative stress are altered in human iPSC-derived neuron and astrocyte co-cultures carrying presenillin-1 gene mutations following spontaneous differentiation. Mol Cell Neurosci. 2021 May 20;114:103631. doi: 10.1016/j.mcn.2021.103631. Epub ahead of print. PMID: 34022327.

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