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  Cell signalling and gene expression dynamics in Drosophila


   Faculty of Biology, Medicine and Health

   Applications accepted all year round  Self-Funded PhD Students Only

About the Project

During Drosophila development, cell signalling and gene expression are regulated in space and time to allow the correct cell fate decisions. The aim of this project is to investigate cell signalling and gene expression dynamics during Drosophila development. This project will use a combination of approaches including CRISPR genome engineering, genetics, and quantitative and live imaging. Results from this project will be relevant to human development and disease, as many of the molecules that control Drosophila development are conserved in humans.

Entry Requirements

Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area/subject : Biology, Developmental Biology, Cell Biology, Genetics.

How To Apply

For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries may be made directly to the primary supervisor. On the online application form select the appropriate subject title.

For international students, we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences.

Equality, Diversity and Inclusion

Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website https://www.bmh.manchester.ac.uk/study/research/apply/equality-diversity-inclusion/”

Biological Sciences (4)

Funding Notes

Applications are invited from self-funded students. This project has a Band 2 fee. Details of our different fee bands can be found on our website View Website

References

Forbes Beadle, L., Love, J.C., Shapovalova, Y., Artemev, A., Rattray, M. and Ashe, H.L. (2022). Modelling global mRNA dynamics during Drosophila embryogenesis reveals a relationship between mRNA degradation and P-bodies. biorxiv 2022.03.17.484585.
Vinter, D.J., Hoppe, C., Minchington, T.G., Sutcliffe C., Ashe, H.L. (2021) Dynamics of hunchback translation in real time and at single mRNA resolution in the Drosophila embryo. Development dev.196121.
Hoppe, C., Bowles, J., Minchington, T.G., Sutcliffe, C., Upadhyai, P., Rattray, M. and Ashe, H.L. (2020). Modulation of the promoter activation rate dictates the transcriptional response to graded BMP signalling levels in the Drosophila embryo. Developmental Cell 54, 727.
Wilcockson, S.G. and Ashe, H.L. (2019). Drosophila ovarian germline stem cell cytocensor projections dynamically receive and attenuate BMP signalling. Developmental Cell 50, 296.

Register your interest for this project