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Cellular mechanisms of nociception in lateral and medial thalamocortical circuits

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  • Full or part time
    Prof A. Groh
    Dr Rebecca Mease
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

Project Description

We are currently seeking a highly motivated and adventurous Ph.D. student to study neuronal and circuit mechanisms of nociception (pain) in the thalamocortical system. The goal of the project is to identify novel, specific circuit interventions to control pain using cutting-edge methods in systems neuroscience. The project combines optogenetics and large-scale electrophysiology in mice and is supported by the second funding period of the Heidelberg Pain Consortium SFB1158 (www.sfb1158.de). Applicants with strong analytical skills and a flair for handling large datasets are particularly encouraged to apply.

Applicants should hold a diploma/Masters in a biomedical discipline (e.g. neuroscience, biology, medicine) or in a quantitative discipline (e.g. physics, informatics, mathematics, biomedical-engineering) or similar. Previous experience in data analysis and programming using MATLAB/Python/R etc. is a prerequisite for the evaluation of your application. Highly desirable but not required: experience in experimental methods to obtain and interpret neurophysiological data, and /or behavioral assays, experience in systems neuroscience or analysis of neural networks; experience in time-series analysis, machine learning, or dynamical systems.

Methods that will be used: electrophysiology, optogenetics, in vivo recordings, behavior, mathematical/computational modeling, patch-clamp, high density silicon probe recordings, cFOS circuit mapping.

Keywords:cortico-subcortical interactions, nociceptive circuits, thalamus, sensori-emotional transformation

The working language in the lab is English.

The project will be conducted at the Groh Lab and is co-PIed by Rebecca Mease, Ph.D. and Prof. Alexander Groh.

Interested? Apply through the Heidelberg Biosciences International Graduate School (HBIGS). http://www.hbigs.uni-heidelberg.de/

Funding Notes

3 years funding available.

References

References:• Multiplexed spike coding and adaptation in the thalamus. R.A. Mease, T. Kuner, A.L. Fairhall, and A. Groh. Cell Reports. (2017).

• Corticothalamic spike transfer via the L5B-POm pathway in vivo. R.A. Mease, A. Sumser, B. Sakmann and A. Groh. Cerebral Cortex. (2016).

• Cortical control of adaptation and sensory relay mode in the thalamus. R.A. Mease, P. Krieger and A. Groh. Proceedings of the National Academy of Sciences USA. (2014).



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