About the Project
In the proposed project, we aim to advance our understanding of the protective role of maintaining cardiac protein homeostasis in diabetes; elucidate novel molecular basis underlying proteotoxicity-induced cardiac dysfuntion; provide new insights into the beneficial effects of preserved protein homeostasis against DCM, as a means of ameliorating the onset and progression of heart failure in diabetes populations.
Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related subject. Candidates with experience in any molecular and cellular techniques or with an interest in diabetes and heart diseases are encouraged to apply.
For international students we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit http://www.internationalphd.manchester.ac.uk
As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit
2. Michael I, Stevens SCW, Schaffer S, Jong CJ, Wold LE. Metabolic dysfunction in diabetic cardiomyopathy. Heart Fail Rev. 2014;19:35-48.
3. McLendon PM, Robbins J. Proteotoxicity and cardiac dysfunction. Circ Res. 2015;116(11):1863-8182.
4. Douglas PM, Cyr DM. Interplay between protein homeostasis networks in protein aggregation and proteotoxicity. Biopolymers. 2010;93(3):229-236.
5. Borghetti G, von Lewinski D, Eaton DM, Sourij H, Houser SR, Wallner M. Diabetic Cardiomyopathy: Current and Future Therapies. Beyond Glycemic Control. Front Physiol. 2018;9:1514.
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