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Several outward potassium currents have been identified in bovine chondrocytes (review Mobasheri et al. 2012). These include ATP-sensitive and a Calcium-activated potassium currents (Sanches & Lopez-Zapata, 2011). Their function is however unknown.
Some studies have previously shown that histamine can increase the outward current through calcium-activated potassium channels, possibly through stimulation of H1 receptors (Funbashi et al 2010). We have found that other hormones and neurotransmitters, such as adrenaline and acetylcholine, can also increases the outward potassium currents in a similar way to histamine. It is possible that these receptors could be manipulated for therapeutic intervention. This project will therefore use a combination of imaging, immunohistochemistry and pharmacological techniques to characterise the types and subtypes of adrenoceptors and muscarinicrecptors that mediate the stimulation of the outward current through calcium-activated potassium. Knowledge and understanding of receptor types in chondrocytes from articular cartilage could contribute the development of drugs that may be used to treat cartilage degradation in disorders such as arthritis and other joint diseases, particularly in the elderly.
Formal applications can be submitted via the University of Bradford web site; applicants will need to register an account and select 'Full-time PhD in Biomedical Science' as the course, and then specify the project title on the 'Research Proposal' tab.
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