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Characterisation of human lung tissue for mechanisms of fibrosis and evaluating novel treatments/fibrosis reversal strategies.

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

This project uses primary human lung tissue sourced via informed consent from patients receiving clinical care in the NHS for lung disease. Lung fibrosis is particularly aggressive in nature, is difficult to treat and has a devastating prognosis for the patient. There is limited information on the causes and mechanisms of disease; this work will characterise lung fibrotic cellular processes for evidence of ‘epithelial to mesenchymal transition,’ a proposed pathological feature of disease. Culture assays will create ‘pro-fibrotic’ conditions to observe pathways of cellular responses; and this model of lung disease will be applied to evaluate actions of novel treatments including poly-unsaturated omega-3 fatty acids (PUFAs) and other isolates from fish oils.

Funding Notes

This PhD is self-funded.

For self-funding PhD / Masters by research applicants with a 2.1 or higher in a relevant Biomedical/biological BSc (hons) only. This work benefits from ongoing collaboration with physicians and surgeons at the University Hospital of South Manchester for sourcing primary human lung material from a range of patients with lung disease with well characterised demographics. Work includes immuno-histochemistry, tissue culture, FACS, DNA and protein characterisation methods.

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