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Characterisation of myeloid cell fate decisions in rheumatic diseases

  • Full or part time
  • Application Deadline
    Thursday, September 12, 2019
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

About This PhD Project

Project Description

The myeloid compartment plays a fundamental role in Rheumatoid Arthritis disease pathogenesis, through the contribution of (a) macrophage to inflammatory cascades and (b) osteoclasts to bone erosion. In the context of this project we aim to investigate the relationship between disease-relevant master regulatory cytokines/growth factors and metabolic profiles, and how combined they influence cell fate decisions in the myeloid compartment. We are, therefore, looking for an applicant who is highly motivated and driven, and acquainted with immunology and/or osteoimmunology. The PhD-student will be responsible for planning, performing and analysing the outcome of experiments, as well as reporting and publishing the results. The project comprises of cellular immunological methods, metabolomics and molecular/epigenetic assays. The analysis of patient-derived sample materials will allow the student to obtain broad knowledge not only in immunology but also in translational immunology with a special focus on arthritis.
The position is part of the EU-funded ArthritisHeal consortium, which is Marie Skłodowska-Curie Actions Innovative training network. The network is aimed at training young researchers to generate novel therapeutic targets in osteoarthritis and rheumatoid arthritis, and is composed of 7 universities and 2 companies. This research will be performed at the department of Immunobiology within the Institute of Infection, Immunity & Inflammation at the University of Glasgow under the supervision of Prof Carl Goodyear. In addition, as the project is embedded in the consortium the young researcher will take part in a comprehensive program of courses and exchange visits between the partner institutions. For example, part of the training may be carried out with our partners from Leuven.

Applicants are expected to have a Master or BSc (2.1 or above) degree in a biomedical science, preferably with experience in cellular immunology and/or macrophage/osteoclast biology. Practical experience with cell culture would be an asset. Additional experiences with molecular cell biology tools (RNAseq or metabolomics) will be considered an advantage. You must be a highly motivated independent team player with a flexible work approach and the ability to work effectively within a multidisciplinary team. English language skills are essential for communication within the team and the consortium, but also for scientific presentations and publications. PhD students involved in this project will make short-term exchange visits with the institutes of the other partners.
Eligibility requirements
According to the regulations for mobility within the ITN programme, the researcher must not have carried out his/her main activity (work, studies, etc) in the country of his/her host organisation (in this case, the United Kingdom) for more than 12 months in the 3 years immediately prior to recruitment.

The researcher should not have obtained a PhD degree and should not have more than 4 year full-time or equivalent research experience since obtaining the degree which makes them eligible for starting the PhD degree.
More information
For more information and details about the project, please go to the ArthritisHeal website ( If you have any questions or would like more information about this vacancy, please contact Professor Carl Goodyear at the University of Glasgow ()

Please complete the online application in English and attach your CV. Please note you will be asked to give a presentation as part of the selection procedure.

The funding for this post is available for 3 years. Interviews for this post are expected to take place at the end of September 2019.

Apply online at:

Closing date: 12 September 2019

It is the University of Glasgow’s mission to foster an inclusive climate, which ensures equality in our working, learning, research and teaching environment.

We strongly endorse the principles of Athena SWAN, including a supportive and flexible working environment, with commitment from all levels of the organisation in promoting gender equity.

The University is committed to equality of opportunity in employment.

The University of Glasgow, charity number SC004401.

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