About the Project
Training/techniques to be provided:
The student will receive training in biochemistry and cell biology, including the growth and differentiation of induced pluripotent stem cells, immunofluorescence microscopy, receptor identification, mass spectrometry, proteomics and bioinformatics analyses.
Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (B.Sc. or equivalent) in a related area / subject (e.g. biochemistry, cell biology, neuroscience) and preferably a master degree in a related area.
For international students we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit http://www.internationalphd.manchester.ac.uk
As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.
Jarosz-Griffiths, H.H., Corbett, N.J., Rowland, H.A., Fisher, K., Jones, A.C., Baron, J., Howell, G.J., Cowley, S.A., Chintawar, S., Cader, M.Z., Kellett, K.A.B. & Hooper, N.M. (2019) J. Biol. Chem. 294, 7085-7097. Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers.
Horton, E.R., Byron, A., Askari, J.A., Ng, D.H.J., Millon-Frémillon, A., Robertson, J., Koper, E.J., Paul, N.R., Warwood, S., Knight, D., Humphries, J.D. & Humphries, M.J. (2015) Nature Cell Biol. 17: 1577-1587. Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly.
Horton, E.R., Humphries, J.D., Stutchbury, B., Jacquemet, G., Ballestrem, C., Barry, S.T. & Humphries, M.J. (2016) J. Cell Biol. 212: 349-364. Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition.
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