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Characterisation vascular function in ischemic heart disease

Project Description

The use of the left internal mammary artery (LIMA) to bypass the left anterior descending artery (LAD) is the “gold standard” for coronary artery bypass grafting. We wish to examine whether the layer of fat around the artery can affect the outcome of bypass, due to the complex milieu of adipokines and cytokines it secretes. This is important clinical investigation due to the obesity epidemic and its association with increased incidence and mortality in many diseases.

This project will seek to

1. Characterise internal mammary artery function in obese/non-obese patients undergoing CABG in relation to adipokine profile and adipose tissue inflammatory status

2. Correlate IMA function, adipokine profile and adipose tissue inflammatory status with successful, infection free coronary artery bypass grafting (CABG). Identify potential circulating biomarkers which are associated with successful outcome to inform best graft choice (IMA or saphenous vein) to achieve successful CABG

Further details:
This is a collaborative, translational project with Nidal Bittar at Blackpool Hospital using patient samples.

Funding Notes

This PhD is self-funded.

We welcome applications from Home/EU and Overseas self-funded students and those seeking their own funding from external sources who meet the entry requirements and are able to cover all the costs, including tuition fees, research costs and living expenses

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