Phosphohistidine is an ubiquitous modification in bacterial cell signaling, however its function in eukaryotic cells has not been defined. In this project, you will combine the use of existing chemical tools with chemical proteomics, biophysics and structural biology to characterize the interaction of known phosphohistidine modifying proteins with their substrates and to identify candidate proteins in human cells capable of acting to controllably remove the modification. The project would suit either a biochemistry or chemistry graduate with an interest in exploring the chemistry/biology interface.
Find out more about the group at our website: http://www.chem.leeds.ac.uk/MEW
White Rose BBSRC Doctoral Training Partnership in Mechanistic Biology 4 year fully-funded programme of integrated research and skills training, starting Oct 2020: • Research Council Stipend • UK/EU Tuition Fees • Conference and research funding
Requirements: At least a 2:1 honours degree or equivalent. We welcome students with backgrounds in biological, chemical or physical sciences, or mathematical backgrounds with an interest in biological questions.
EU candidates require 3 years of UK residency to receive full studentship
Not all projects will be funded; the DTP will appoint a limited number of candidates via a competitive process.