About the Project
An intriguing example is the carboxysome, which significantly enhances photosynthetic carbon fixation in cyanobacteria. Carboxysomes are composed of hundreds of proteins that self-assemble, in a precise and regulatory manner, to form a highly-organised and functional architecture. These bacterial organelles offer great opportunities for bioengineering of metabolic modules using synthetic biology.
This project will use multidisciplinary approaches to study how carboxysomes are constructed in nature and how to engineer carboxysomes with new functions in other hosts using synthetic biology. Understanding the principles of carboxysome assembly is important for building new bio-nanoreactors and protein scaffolds in other organisms to enhance metabolism. It has the potential to revolutionise crop engineering, bioenergy production and therapeutic development.
Contact: Dr. Luning Liu, [Email Address Removed], www.luningliu.org
2. Faulkner M, Rodriguez-Ramos J, Dykes GF, Owen SV, Casella S, Simpson DM, Beynon RJ, Liu LN. Direct characterization of the native structure and mechanics of cyanobacterial carboxysomes. Nanoscale, 2017, 9(30): 10662-10673
3. Sun Y, Casella S, Fang Y, Huang F, Faulkner M, Barrett S, Liu LN. Light modulates the biosynthesis and organization of cyanobacterial carbon fixation machinery through photosynthetic electron flow. Plant Physiology, 2016, 171(1): 530-541.
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