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Characterising antibiotic-induced collateral damage in the gut microbiome


   Sir William Dunn School of Pathology

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  Dr Mathew Stracy  No more applications being accepted  Competition Funded PhD Project (Students Worldwide)

About the Project

Antibiotics help clear an ongoing infection, but they can also cause significant collateral damage: they select for drug-resistant strains and cause dysbiosis to the commensal gut microbiota. This antibiotic-induced selection for resistance within the microbiome can facilitate the spread of resistant pathogens to extra-intestinal infections and to other patients (see our previous work: Stracy et al. Science. 2022, 375 (6583), 889-894).

This project will aim to understanding how antibiotics cause collateral damage to the microbiota. This will involve experiments with synthetic and natural microbial communities as well as developing microscopy methods to understand the effect of antibiotics on the micro-scale biogeography of the microbiota. The aim is to characterise the key factors that determine how antibiotics affect a patient’s resident microbial population and cause resistant pathogens to spread. This will be used to help develop new ways to minimize the spread of antibiotic resistance both within and between patients.

The project would suit applicants with a strong background in microbiology and keen interest in developing new ways to combat antibiotic resistance. 


Funding Notes

4 Year DPhil Prize Studentships cover University fees, a tax free stipend of ~£20,168 pa, and up to £5,300 pa for research costs and travel. The competition is open to applicants from all countries. See https://www.path.ox.ac.uk/content/departmental-prize-dphil-studentship-competition-2023 for full details and to apply.

References

Stracy et al. Minimizing treatment-induced emergence of antibiotic resistance in bacterial infections. 2022. Science 375 (6583), 889-894
Stracy. Microbiome cartography. 2022. Nature Reviews Microbiology 20 (6), 319-319

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