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Characterising estrogen receptor associated factors in breast cancer

  • Full or part time
  • Application Deadline
    Friday, November 15, 2019
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

Project Description

Estrogen Receptor (ER) is the defining feature of luminal breast cancers, where it functions as a transcription factor. ER utilises a number of associated proteins to effectively maintain DNA interactions and regulate the target genes that culminate in cell division. We have recently developed a quantitative proteomic method called qPLEX-RIME that permits unbiased discovery of protein-protein interactions from clinical tissue. This has revealed many hundreds of putative novel ER-regulatory proteins. When coupled with CRISPR screening data, there are more than 100 ER-associated proteins that are also required for ER transcriptional activity. This project will focus on defining key candidates within these datasets that are differentially associated with ER in different stages of disease progression, with a focus on the proteins that contribute to drug resistance. Specifically, the project will involve characterisation of key candidate proteins that modulate ER activity. In addition, the project will involve detailed identification of the changes in protein interactions that occur during disease progression from primary tumours to metastases. Detailed functional assessment of candidate factors will be conducted and the potential role in mediating ER function will be defined.

Preferred skills/knowledge
The student will have either a Masters research degree or an excellent undergraduate degree plus additional wet lab experience. Previous experience in cell culture, molecular biology and biochemistry assays is required. Any previous experience in cancer research is also expected and genomic/proteomic experience would be a benefit, but is not essential.

Please click on ’Visit Website’ for details on how to apply. You must submit an application on-line to be considered for this studentship.

Funding Notes

Funding
This project is funded by a Cancer Research UK studentship that includes full funding for University and College fees and a stipend of £19,000 per annum. The study start date will be October 2020 (Michaelmas term 2020).

Eligibility
No nationality restrictions apply to Cancer Research UK funded studentships. Applications are invited from recent graduates or final year undergraduates who hold or expect to gain a first/upper second class degree (or equivalent) in a relevant subject from any recognised university worldwide.

How good is research at University of Cambridge in Clinical Medicine?

FTE Category A staff submitted: 192.05

Research output data provided by the Research Excellence Framework (REF)

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