About the Project
The aim of this project is to develop new approaches for the characterisation and probing of protein surface properties using solution NMR spectroscopy, and correlate these with theoretical calculations using the 3D structure of these proteins.
This multidisciplinary project will be carried out under the supervision of Drs Alexander Golovanov and Jim Warwicker. The student will receive extensive training in modern high-resolution multi-dimensional NMR techniques, protein modelling and computational biology. The School of Chemistry has state-of-the-art research facilities, including recent investment in the NMR facility that is now equipped with multichannel 500, 600 and 800 MHz spectrometers with cyroprobes. The supervisory team has strong links with industry, which will help to disseminate/ commercialise the discoveries made in this project to the biotechnology and biopharmaceutical sectors.
Contact for further Information:
Dr Alexander Golovanov [Email Address Removed]
Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or the overseas equivalent) in a related area / subject. Candidates with experience in molecular biology or with an interest in structural biology and NMR spectroscopy are encouraged to apply.
Please select PhD Biotechnology on the online application form.
Kheddo P, Bramham JE, Dearman RJ, Uddin S, van der Walle CF, Golovanov AP. Investigating Liquid-Liquid Phase Separation of a Monoclonal Antibody Using Solution-State NMR Spectroscopy: Effect of Arg·Glu and Arg·HCl. Mol Pharm. 2017 Aug 7;14(8):2852-2860.
Austerberry JI, Dajani R, Panova S, Roberts D, Golovanov AP, Pluen A, van der Walle CF, Uddin S, Warwicker J, Derrick JP, Curtis R. The effect of charge mutations on the stability and aggregation of a human single chain Fv fragment. Eur J Pharm Biopharm. 2017 Jun;115:18-30.
Kheddo P, Cliff MJ, Uddin S, van der Walle CF, Golovanov AP. Characterizing monoclonal antibody formulations in arginine glutamate solutions using 1H NMR spectroscopy. MAbs. 2016 Oct;8(7):1245-1258.
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