Immunotherapy been demonstrated as an effective treatment with great benefits in cancer, however there remains much scope for improvement and better mechanistically understanding. This project to discover the immunopeptidome will focus on head & neck cancers. The PhD candidate will use and develop experimental and computational proteogenomics methods to understand the antigenic drivers of immune response in head and neck cancer. The project will use state of the art mass spectrometry to develop and apply proteomics to discover the immunopeptidome in cell lines and tissues. This highly multidisciplinary PhD will offer a broad range of training in state of the art proteomics mass spectrometry, immunology, cell biology, tissue culture and bioinformatics. There will be exposure to the fields of protein structure and radiotherapy through interactions with groups in the Institute and Royal Marsden Hospital.
Candidates must have a first class or upper second class honours BSc Honours/MSc in Biology, Biochemistry or Chemistry.
How to apply
Full details about these studentship projects, and the online application form, are available on our website, at: http://www.icr.ac.uk/phds Applications for all projects should be made online. Please ensure that you read and follow the application instructions very carefully.