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Characterising the immunopeptidome by proteogenomics and elucidating their associated immune response in head and neck cancer

  • Full or part time
    Dr J Choudhary
  • Application Deadline
    Friday, March 29, 2019
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

Project Description

Immunotherapy been demonstrated as an effective treatment with great benefits in cancer, however there remains much scope for improvement and better mechanistically understanding. This project to discover the immunopeptidome will focus on head & neck cancers. The PhD candidate will use and develop experimental and computational proteogenomics methods to understand the antigenic drivers of immune response in head and neck cancer. The project will use state of the art mass spectrometry to develop and apply proteomics to discover the immunopeptidome in cell lines and tissues. This highly multidisciplinary PhD will offer a broad range of training in state of the art proteomics mass spectrometry, immunology, cell biology, tissue culture and bioinformatics. There will be exposure to the fields of protein structure and radiotherapy through interactions with groups in the Institute and Royal Marsden Hospital.

Download a PDF of the complete project proposal: https://d1ijoxngr27nfi.cloudfront.net/docs/default-source/studying-at-the-icr/studentships-2018/main-round-of-studentships/4_choudhary_melcher_harrington_icr-studentship.pdf?sfvrsn=57eb5e69_2

Candidate profile

Candidates must have a first class or upper second class honours BSc Honours/MSc in Biology, Biochemistry or Chemistry.

How to apply

Full details about these studentship projects, and the online application form, are available on our website, at: http://www.icr.ac.uk/phds Applications for all projects should be made online. Please ensure that you read and follow the application instructions very carefully.

Closing date: Friday 29th March 2019

Please apply via the ICR vacancies web portal
https://www.icr.ac.uk/studying-at-the-icr/phds-for-science-graduates/phd-studentship-projects

Funding Notes

Full funding is available

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