University of Edinburgh Featured PhD Programmes
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Characterising the immunopeptidome by proteogenomics and elucidating their associated immune response in head and neck cancer

  • Full or part time
    Dr J Choudhary
    Prof K Harrington
    Prof A Melcher
  • Application Deadline
    Sunday, November 17, 2019
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

About This PhD Project

Project Description

The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes. We are committed to attracting and developing the best minds in the world to join us in our mission—to make the discoveries that defeat cancer.

Characterising the immunopeptidome by proteogenomics and elucidating their associated immune response in head and neck cancer

Project Description:
Immunotherapy been demonstrated as an effective treatment with great benefits in cancer, however there remains much scope for improvement and better mechanistically understanding. This project to discover the immunopeptidome will focus on head & neck cancers. The PhD candidate will use and develop experimental and computational proteogenomics methods to understand the antigenic drivers of immune response in head and neck cancer. The project will use state of the art mass spectrometry to develop and apply proteomics to discover the immunopeptidome in cell lines and tissues. This highly multidisciplinary PhD will offer a broad range of training in state of the art proteomics mass spectrometry, immunology, cell biology, tissue culture and bioinformatics. There will be exposure to the fields of protein structure and radiotherapy through interactions with groups in the Institute and Royal Marsden Hospital.

Keywords:
Proteomics
Immunology
Genomics
Cancer Therapy
Quantitative biology
Bioinformatics


Funding Notes

Students receive an annual stipend, currently £21,000 per annum, as well as having tuition fees (both UK/EU and overseas) and project costs paid for the four-year duration. We are open to applications from any eligible candidates and are committed to attracting and developing the best minds in the world.
See icr.ac.uk/phds to apply
Applications close 11:55pm UK time on Sunday 17th November 2019

Candidates must have a first class or upper second class honours BSc Honours/MSc in Biology, Biochemistry or Chemistry.



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