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Characterising the translatability of mice models of Alzheimer’s disease (AD): a behavioural comparison of multiple memory functions in humans and mice

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  • Full or part time
    Dr Carlo De Lillo
    Dr T Gerdjikov
    Prof E Mukaetova-Ladinska
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Transgenic mice models of Alzheimer’s disease (AD) could be a powerful tool for fighting dementia. They could enable trialling interventions in mice that are likely to translate into improved cognition in patients. Nonetheless, translating findings from these models into successful clinical trials in people is proving challenging. A reason for this is the lack of tests for comparable cognitive assessment of people and mice. This project features the use an innovative search/foraging task that enables the measurement of several memory functions in mice (tested in an open arena) and people (tested in virtual reality). The project involves comparing memory functions in people diagnosed with AD, mice models of AD and control groups of both species. The outcomes will have both translational and theoretical value. They will include the validation of animal models of human disease, the development and validation of a new tool for cognitive assessment and the advancement of knowledge on the pattern of cognitive decline in ageing and dementia. The supervisory team includes an experimental psychologist, a neuroscientist and a psychiatrist of old age. The project will equip the student with skills including animal testing, human cognitive assessment, expertise in the use of advanced technology and data-analysis.

Entry requirements:
You must hold (or be about to obtain) a First or an Upper Second Class UK undergraduate degree or an equivalent degree from a recognised EU institution, in an area relevant to the projects you are applying for.

Qualifications (or a combination of qualifications and experience) which demonstrate equivalent ability and attainment will also be considered.

For example, a less than sufficient first degree may be enhanced to meet the requirements by the acquisition of a Distinction at Masters level or significant research experience gained from employment).

Informal enquiries:
If you have any questions or would like to find out more about IMPACT, please get in touch.
Email us at [Email Address Removed]

Eligibility:
UK/EU applicants only

To apply:
Please refer to https://more.bham.ac.uk/mrc-impact/phd-opportunities/

Funding Notes

The Studentship provides 3.5 years of Stipend at UKRI rates and Tuition fees at UK/EU rates.



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