Characterization of a Novel Human Myokine
Skeletal muscle, in addition to its traditional role in movement in the body, is involved in regulating physiological homeostasis and disease progression in other tissues. Specifically, muscle can release proteins known as myokines which can influence insulin sensitivity and inflammatory responses in other metabolic tissues such as adipose tissue and the liver. To date only four genuine myokines – muscle secreted proteins shown to act on other tissues – have been discovered. Our group has recently identified a novel myokine, a lipid binding protein that can be secreted from primary human skeletal muscle cells in response to changes in fatty acid and glucose availability and also when the cells are electrically stimulated to cause contraction.
This project will involve the characterization of the pathways that induce secretion of the novel myokine and determining its effects upon insulin signalling and metabolic control of adipose tissue and liver.
The University of Nottingham is one of the world’s most respected research-intensive universities, ranked 8th in the UK for research power (REF 2014). Students studying in the School of Life Sciences will have the opportunity to thrive in a vibrant, multidisciplinary environment, with expert supervision from leaders in their field, state-of-the-art facilities and strong links with industry. Students are closely monitored in terms of their personal and professional progression throughout their study period and are assigned academic mentors in addition to their supervisory team. The School provides structured training as a fundamental part of postgraduate personal development and our training programme enables students to develop skills across the four domains of the Vitae Researcher Development Framework (RDF). During their studies, students will also have the opportunity to attend and present at conferences around the world. The School puts strong emphasis on the promotion of postgraduate research with a 2-day annual PhD research symposium attended by all students, plus academic staff and invited speakers.
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How good is research at University of Nottingham in Biological Sciences?
FTE Category A staff submitted: 90.86
Research output data provided by the Research Excellence Framework (REF)
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