Characterization of clonal evolution of T-cell lymphoma

It has long been assumed that malignant T-cell lymphoma is a monoclonal disease. i.e. the tumour grows and expands from a single cell. In contrast to this traditional view, our ongoing investigations show for the first time evidence of bi- or oligo-clonal T-cell populations in angioimmunoblastic T-cell lymphoma and its related entities. It is imperative to investigate whether each of these different clonal T-cell populations in a T-cell lymphoma is neoplastic, derived from a common progenitor cell population, and how they impact on disease presentation and treatment responses.

Full details of the projects and how to apply are available from the following link: http://www.path.cam.ac.uk/graduate/fully-funded-studentships.
*Please quote reference PK17049 on your application and in any correspondence about this vacancy.