Imperial College London Featured PhD Programmes
Imperial College London Featured PhD Programmes
Norwich Research Park Featured PhD Programmes
Norwich Research Park Featured PhD Programmes
University of Reading Featured PhD Programmes

Characterization of monoallelic regulation variation and aneuploidy associated dosage compensation mechanisms in human pre-implantation embryos (MONKU20DTP1)

  • Full or part time
  • Application Deadline
    Monday, November 25, 2019
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

We are developing and applying computational and experimental methods to help decipher the underlying reason why some human embryos undergo spontaneous developmental arrest. Using cutting-edge single-cell (epi)genomic and transcriptomic tools, we hope to provide new insights into the establishment of monoallelic gene regulation (genomic imprinting, X-inactivation and eQTLs) in mediating embryo development and in utero growth.

We are looking for an enthusiastic and ambitious student to develop and apply sophisticated data- mining methods and computational models at the interface of biology, mathematics and computer science. The project is a joint Norwich Research Park venture between the groups of David Monk at the Biomedical Research Centre, University of East Anglia and Wilfried Haerty at the Earlham Institute. Though this project is primarily computational, we have extensive wet lab facilities and thus it is possible to experimentally validate any computational predictions emerging from this project.

This candidate will be put forward for selection in the Norwich Research Park (NRP) Doctoral Training Partnership program. Successful candidates will receive a rich and diverse training in bioinformatics techniques related to transcriptomics and human development. In addition to the generic skills training that is provided through the UEA/EI PhD NRPDTP programme, the student will be supported by an excellent infrastructure and will work closely with experts on the biology and next generation sequencing and (epi)genomics. This diverse and stimulating environment will allow a creative and talented student to develop key skills in preparation for a successful career in research and industry.

Project supervisor:
Project sponsor: Norwich Research Park Bioscience Doctoral Training Partnership
Type of programme: PhD
Start date: 1 October 2020
Mode of study: Full-time
Studentship length: 4 years


- First degree (2:1 or above) in relevant subject
- English language (IELTS 6.5 overall, 6 in each section)


This project has been shortlisted for funding by the Norwich Biosciences Doctoral Training Partnership (NRPDTP). Shortlisted applicants will be interviewed as part of the studentship competition. Candidates will be interviewed on either the 7th, 8th or 9th January 2020.

The NRP DTP offers postgraduates the opportunity to undertake a 4-year research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP students undertake a three-month professional internship (PIPS) during their study. The internship offers exciting and invaluable work experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team. Students with, or expecting to attain, at least an upper second class honours degree, or equivalent, are invited to apply.

For further information and to apply, please visit our website:

Funding Notes

For funding eligibility guidance, please visit our website: View Website. Full Studentships cover a stipend (2019/0 rate: £15,009pa), research costs and tuition fees at UK/EU rate and are available to UK and EU students who meet the UK residency requirements.

Students from EU countries who do not meet the UK residency requirements may be eligible for a fees-only award. Students in receipt of a fees-only award will be eligible for a maintenance stipend awarded by the NRPDTP Bioscience Doctoral Scholarships. To be eligible students must meet the EU residency requirements.

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