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Characterization of the roles of PP1 phosphatases in cytokinesis

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  • Full or part time
    Dr P D'Avino
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

All biological processes are controlled and executed by proteins, whose function is regulated in space and time by post-translational modification (PTMs). Reversible PTMs, such as phosphorylation, are essential for the proper activity of many signalling pathways and networks that control almost every cellular and developmental process. Unsurprisingly, de-regulation of phosphorylation signalling pathways has been associated with many human disease, including cancer. Cell division represents an ideal system to study phosphorylation because gene transcription is severely limited by the inaccessibility of DNA. The identity and function of mitotic kinases have been studied is some detail, but very little is known about their counteracting phosphatases. The aim of this project is to characterize the roles of PP1 phosphatases during mitosis using a multi-systems approach combining gene editing, quantitative proteomics and multi-dimensional high resolution microscopy.

Full details of the projects and how to apply are available from the following link: http://www.path.cam.ac.uk/graduate/fully-funded-studentships.
*Please quote reference PK17049 on your application and in any correspondence about this vacancy.

Funding Notes

The studentships are available to students who qualify for Home/EU fees. Further information at: http://www.graduate.study.cam.ac.uk/finance/fees/what-my-fee-status
Funding will cover the student's stipend at the current Research Council rate and University Fees. The studentships will be funded for three years in the first instance subject to eligibility with the possibility of additional funding in the fourth year depending on circumstances.

Applicants should hold or be about to achieve a First or Upper-Second (2.i) class degree in a relevant subject.
By time of interview all potential students must have fulfilled language requirements for admission.
(http://www.graduate.study.cam.ac.uk/courses/directory/blpapdpth/requirements).

Applications from ineligible candidates will not be considered.



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