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Characterization of the roles of PP1 phosphatases in cytokinesis

  • Full or part time
  • Application Deadline
    Thursday, January 03, 2019
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Cell division faithfully partitions the genomic information between the two daughter cells and errors in this process have been implicated in many human diseases. Most mitotic events are regulated by phosphorylation and, although mitotic kinases have been studied is some detail, very little is known about their counteracting phosphatases. We have recently characterised the protein interaction network in the last phase of mitosis, cytokinesis, and found that PP1 phosphatases were the most abundant and frequent. The aim of this project is to characterize the roles of these phosphatases during cytokinesis using a multi-systems approach combining gene editing, quantitative proteomics, and multi-dimensional high resolution microscopy.

Full details of the projects and how to apply are available from the following link:
*Please quote reference PK17049 on your application and in any correspondence about this vacancy.

Funding Notes

The studentships are available to students who qualify for Home/EU fees. Further information at: View Website
Funding will cover the student's stipend at the current Research Council rate and University Fees. The studentships will be funded for three years in the first instance subject to eligibility with the possibility of additional funding in the fourth year depending on circumstances.

Applicants should hold or be about to achieve a First or Upper-Second (2.i) class degree in a relevant subject.
By time of interview all potential students must have fulfilled language requirements for admission.
(View Website).

Applications from ineligible candidates will not be considered.

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