Characterization of the roles of PP1 phosphatases in cytokinesis
All biological processes are controlled and executed by proteins, whose function is regulated in space and time by post-translational modification (PTMs). Reversible PTMs, such as phosphorylation, are essential for the proper activity of many signalling pathways and networks that control almost every cellular and developmental process. Unsurprisingly, de-regulation of phosphorylation signalling pathways has been associated with many human disease, including cancer. Cell division represents an ideal system to study phosphorylation because gene transcription is severely limited by the inaccessibility of DNA. The identity and function of mitotic kinases have been studied is some detail, but very little is known about their counteracting phosphatases. The aim of this project is to characterize the roles of PP1 phosphatases during mitosis using a multi-systems approach combining gene editing, quantitative proteomics and multi-dimensional high resolution microscopy.
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