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Chemical and biological studies on antibiotics to Target Bacterial Cell wall Synthesis

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  • Full or part time
    Dr Ishwar Singh
  • Application Deadline
    Applications accepted all year round
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Fee Waiver Scholarships for MSc by Research

Chemical and biological studies on antibiotics to Target Bacterial Cell wall Synthesis
The increasing bacterial resistance against currently used antibiotics and lack of new antibiotics to combat antimicrobial resistance (AMR) are major challenges to global health and wealth. These major challenges are estimated to cause 10 million deaths every year and $ 100 trillion in lost productivity to the global economy by 2050. There is therefore an urgent need to develop new classes of antibiotics against resistant bacterial infections.

To address the challenges from AMR, we are developing new classes of antibiotics such as synthetic teixobactins. Teixobactins kill the multi-drug resistant bacterial pathogens without detectable resistance. Some of our contributions to the area are given below.
Open access article
https://pubs.rsc.org/en/content/articlelanding/2017/sc/c7sc03241b#!divAbstract
Open access article featured on Chem Comm cover
http://pubs.rsc.org/en/Content/ArticleLanding/2016/CC/C5CC10249A#!divAbstract


Global battle waged against Superbugs
https://www.chinadailyasia.com/articles/211/123/238/1536912826589.html?newsId=48185
10 million lives could be lost to superbugs – so how far have we got in the race to beat them?
https://www.telegraph.co.uk/health-fitness/body/10-million-lives-could-lost-superbugs-far-have-got-race-beat/
Breakthrough on road to superbug-killing antibiotic
http://www.itv.com/news/calendar/2018-03-26/breakthrough-on-road-to-superbug-killing-antibiotic/
Simplified structure eases antibiotic synthesis
https://www.chemistryworld.com/news/simplified-structure-eases-antibiotic-synthesis/3007718.article
Molecular structure is teixobactin’s pièce de résistance
https://www.chemistryworld.com/news/molecular-structure-is-teixobactins-pi%C3%A8ce-de-r%C3%A9sistance/2500349.article
Project: In this project, you will have opportunity to work on synthetic teixobactins and other antimicrobials targeting bacterial cell using chemical and biological approaches. If you wish to discuss it further please get in touch with Dr Ishwar Singh e-mail: [Email Address Removed]

Funding Notes

Fee Waiver Scholarships for MSc by Research in new classes of Antibiotic: Synthetic Teixobactins (EU and UK Students Only)

How good is research at University of Lincoln in Allied Health Professions, Dentistry, Nursing and Pharmacy?

FTE Category A staff submitted: 19.40

Research output data provided by the Research Excellence Framework (REF)

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