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Chemical biology tools for imaging, targeting and isolation of putative pharmaceutic targets

Project Description

We have recently developed a modular system of polymer “synthetic antibodies” (iBodies) that allow for visualisation and isolation of target molecules based on specific interaction between the protein target and small molecule ligand (Šácha et al., 2016). iBodies: Modular Synthetic Antibody Mimetics Based on Hydrophilic Polymers Decorated with Functional Moieties. Angew. Chem. Int. Ed. Engl. 55, 2356-2360). We continue to apply this tool for a variety of targets including membrane and cellular proteases, carbonic anhydrases and immune cell receptors. The successful applicant will develop novel iBodies against medicinally relevant targets, will design or select specific low-molecular ligands of these targets and analyze the interaction of corresponding macromolecule conjugates with the target. The iBodies will be used for the visualisation, separation and identification of novel targets of known biologically active compounds.
We look for highly motivated candidate enjoying work in multidisciplinary team capable of working at the interface between molecular biology, biochemistry, structural biology and medicinal chemistry. The methods actively used involve recombinant DNA cloning, protein expression and characterization, X-ray and NMR structural biology, immunochemistry and transgenic mice.

How to apply

To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.

For more information visit our website “Call for PhD applications 2019”:

You can apply online via our application form


All general enquiries should be directed to Katerina Solcova (). Scientific enquiries can be addressed to the supervisors ( or )

Funding Notes

Šácha, P., Knedlík, T., Schimer, J., Tykvart, J., Parolek, J., Navrátil, V., Dvořáková, P., Sedlák, F., Ulbrich, K., Strohalm, J., Majer, P., Šubr, V., Konvalinka J. (2016). iBodies: Modular Synthetic Antibody Mimetics Based on Hydrophilic Polymers Decorated with Functional Moieties. Angew. Chem. Int. Ed. Engl. 55, 2356-2360
Šimon, P., Knedlík, T., Blažková, K., Dvořáková, P., Březinová, A., Kostka. L., Šubr, V., Konvalinka, J. and Šácha, P. (2018). Identification of Protein Targets of Bioactive Small Molecules Using Randomly Photomodified Probes, ACS Chem. Biol. 13, 3333-3342, DOI: 10.1021/acschembio.8b00791


Regular monthly income of students at IOCB Prague varies depending on the faculty scholarship and supervisor's financial options.

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