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Chemical or enzymatic labelling of epigenetic nucleobases in DNA

  • Full or part time
    Prof M Hocek
  • Application Deadline
    Sunday, February 23, 2020
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

New biocompatible chemical or enzymatic reactions will be studied and developed for modification of epigenetic bases (e.g. 5hmC, 5hmU, 5fC, etc.). These reactions will be then applied in labeling, imaging or sequencing of the epigenetic nucleobases in DNA.

How to apply

To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.

For more information visit our website “Call for PhD applications 2020”:
https://www.uochb.cz/en/phd-program

If you decided to apply, please do so online via our application form:
https://www.uochb.cz/en/call-for-phd-applications

Funding Notes

Regular monthly income of students at IOCB Prague varies depending on the faculty scholarship and supervisor's financial options.

References

Vaníková, Z.; Janoušková, M.; Kambová, M.; Krásný, L.; Hocek, M. "Switching transcription with bacterial RNA polymerase through photocaging, photorelease and phosphorylation reactions in the major groove of DNA" Chem. Sci. 2019, 10, 3937-3942.

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