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Chemical probes to investigate mechanisms of bacterial resistance

Department of Chemistry

About the Project

Antibiotic resistance is seen as a significant threat to modern healthcare, especially in light of an increasing and aging population who will place additional burden on this sector. In recent years, development of new antibiotics has stalled in-part due to a lack of clear understanding of how some antibiotics actually cause bacterial cell death, and also from a lack of new molecular targets. This project aims to more fully investigate these areas by chemically modifying known antibiotics to incorporate molecular dyes that can then be used to investigate mode of action of known or new targets using state of the art imaging facilities. The project will involve synthetic organic chemistry, basic microbiology, and cellular imaging that will deliver molecular scale insights that could inform the next generation of antibiotics or new biological targets.

Funding Notes

This is a self-funded project.

You should have or expect to gain at least an upper second class degree, or equivalent, in a relevant subject.

If you have the correct qualifications and access to your own funding, either from your home country or your own finances, your application to work with this supervisor will be considered.

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