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Chemical probes to profile tissue microenvironments


Project Description

A PhD studentship is available jointly between the groups of Professor Colin Campbell (School of Chemistry, The University of Edinburgh http://www.chem.ed.ac.uk/staff/academic-staff/professor-colin-campbell and Dr Marc Vendrell, Centre for Inflammation Research, The University of Edinburgh http://www.dynafluors.co.uk

Reference Number PHD19CJC2

Project Summary
Regeneration of tissues is a key process in many disorders, including inflammatory diseases, neurodegeneration and cancer. There is a lack of understanding on how tissue microenvironments are affected by such chemical components as pH, oxygen concentration, metabolite concentration and enzyme activity, and how these determine whether tissue regenerates well or not.

This is an interdisciplinary project -supported by an ERC Consolidator Grant- at the interface of organic chemistry, chemical biology and molecular imaging. Candidates are expected to have solid background in at least one of these areas and a strong interest in being trained as a multidisciplinary researcher. The main aims of the project are the design, synthesis, characterization and biological evaluation of a toolbox of new chemical reporters to profile live tissue microenvironments.
The candidate will work in between the School of Chemistry and the Centre of Inflammation Research, working in a world-class research environment at the interface between biological and medical science with multidisciplinary groups focused on chemistry, inflammation, cancer and regeneration. The Centre for Inflammation Research is based within the Edinburgh Medical School in the outstanding facilities of the Queen’s Medical Research Institute at the site of the Royal Infirmary of Edinburgh hospital, maximising future translational opportunities.

The studentship will be awarded competitively. Applicants should hold or expect a first class or upper second class degree in organic chemistry or chemical biology.
In the first instance, informal enquiries (accompanied by a CV) should be directed to:
Dr Marc Vendrell, Centre for Inflammation Research, The University of Edinburgh.
Email:

The position will remain open until filled.

Equality and Diversity
The School of Chemistry holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. The University is a member of the Race Equality Charter and is a Stonewall Scotland Diversity Champion, actively promoting LGBT equality. The University has a range of initiatives to support a family friendly working environment. See our University Initiatives website for further information. University Initiatives website: https://www.ed.ac.uk/equality-diversity/help-advice/family-friendly.

Funding Notes

The studentship is fully funded for 42 months and covers tuition fees and an annual stipend (starting at £15,009 per annum) for a candidate satisfying EPSRC criteria:
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How good is research at University of Edinburgh in Chemistry?
(joint submission with University of St Andrews)

FTE Category A staff submitted: 43.30

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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