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Chemical proteomics of multisite fungicides


   Department of Chemistry

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  Prof Andrew Pitt, Prof J Micklefield  No more applications being accepted  Funded PhD Project (European/UK Students Only)

About the Project

This PhD project, run in collaboration with Syngenta (https://www.syngenta.com/en) and part funded by CAMS (Community for Analytical Measurement Science, https://cams-uk.co.uk/) and the University of Manchester, will use chemical biology approaches to provide a comprehensive understanding of the target profile of multi-site reactive fungicides, and use this information to determine how the cidal effect and off-target toxicities are mediated at a molecular level. This project will develop methods to synthesise the probes, detect the proteins modified by reactive fungicides in target and non-target organisms, and determine the biological significance of these effects. 

The project will involve: 1) the synthesis of modified analogues of multisite fungicides and determination of their antifungal activity, and redesign and synthesis of the probes as necessary; 2) the detection of the proteins which the analogues interact with in the target, host and mammalian systems, using LCMS-based chemical proteomics; 3) the use of this information to explore the molecular basis for on- and off-target effects; and 4) the identification of the dose-dependent changes in modification to demonstrate that the identified modifications are biologically relevant in the system being studied.

Applicants are expected to hold, or be about to obtain, a minimum upper second class undergraduate degree (or equivalent) in chemistry or a closely related subject. A Masters degree in a relevant subject and/or experience in chemical synthesis or chemical proteomics would be beneficial but is not essential.

 http://www.chemistry.manchester.ac.uk/study/postgraduate/researchdegrees/howtoapply/

Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. We know that diversity strengthens our research community, leading to enhanced research creativity, productivity and quality, and societal and economic impact. We actively encourage applicants from diverse career paths and backgrounds and from all sections of the community, regardless of age, disability, ethnicity, gender, gender expression, sexual orientation and transgender status.

 We also support applications from those returning from a career break or other roles. We consider offering flexible study arrangements (including part-time: 50%, 60% or 80%, depending on the project/funder). 


Funding Notes

The award will cover stipend at the UKRI rate and UK fees. The School contribution will cover the stipend and fees for 3.5 years. The contribution from CAMS (£30k) will cover instrument costs, consumables, travel, etc.

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