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Chemical synthesis of hypermodified oligonucleotides and DNA

  • Full or part time
    Prof M Hocek
  • Application Deadline
    Sunday, February 23, 2020
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Chemical synthesis of hypermodified oligonucleotides and DNA stretches will be studied and developer using novel base-modified nucleoside phosphoramidites. The modifications will include e.g. hydrophobic substituents, heterocycles or sugars. In some cases, orthogonal protecting group strategy will have to be developed. Hybridization and folding of these oligomers will be also studied as well as their interactions with proteins and biological activity.

How to apply

To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.

For more information visit our website “Call for PhD applications 2020”:
https://www.uochb.cz/en/phd-program

If you decided to apply, please do so online via our application form:
https://www.uochb.cz/en/call-for-phd-applications

Funding Notes

Regular monthly income of students at IOCB Prague varies depending on the faculty scholarship and supervisor's financial options.

References

Seo, Y. J.; Malyshev, D. A.; Lavergne, T.; Ordoukhanian, P.; Romesberg, F. E. Site-specific Labeling of DNA and RNA Using an Efficiently Replicated and Transcribed Class of Unnatural Base Pairs. J. Am. Chem. Soc. 2011, 133, 19878–19888.

Related Subjects



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