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China Scholarship Council - Intellectual disability in patients with mutations in O-GlcNAc transferase

  • Full or part time
  • Application Deadline
    Wednesday, January 15, 2020
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

The School of Life Sciences at the University of Dundee, joint with the China Scholarship Council (CSC), is proud to be able to offer a scholarship programme for postgraduate research students. The scholarship covers all tuition fees and research fees and provides living expenses and one return flight ticket to successful candidates. There are up to 5 scholarships of 4 years duration available.

Project Description

Intellectual disability (ID) and associated developmental delay are severe neurodevelopmental conditions that affect approximately 1% of the world population. 5% -10% of ID cases are due to mutations in genes located on the X chromosome. One of the genes shown to co-segregate with X-linked intellectual disability (XLID) in twelve patients is the gene ogt. Ogt encodes an essential enzyme, the O-GlcNAc transferase, which catalyses an abundant nucleocytoplasmic post-transcriptional modification O-GlcNAcylation. We have recently described this as a novel syndromic form of XLID (“OGT-XLID”) and are now pursuing four possible hypotheses for underpinning biological mechanisms, potentially revealing possible future targets for treatment. In your project you could, depending on your interests, interact with clinicians who have found novel OGT mutations from exsome sequencing and use, depending on your interests, a number of possible techniques to study the effects of these mutations. This ranges from biochemical, molecular, cell biological to genetic techniques in model systems ranging from in vitro biophysical/chemistry approaches to genetic approaches in stem cells, flies and mice. You will receive expert supervision within the context of an established and well-funded lab. There may be chances for you to interact with our satellite lab at Xiangya Hospital in Changsha. We would aim for your experiments to form the basis of several high quality scientific publications, as has been the case for the 22 PhD students that have passed through the lab so far. We are looking for hard working, self-driven and independently thinking students. Contact me for an informal chat on

Funding Notes

In order to be eligible for these awards applicants must:

Be a Chinese national
Meet the requirements of the CSC – please see their website
Hold an unconditional offer to study for a PhD at the University of Dundee and meet our English language requirements
Have completed bachelors or masters degree before the agreed start of PhD study.

References

N. Selvan, R. Williamson, D. Mariappa, D.G. Campbell, R. Gourlay, A.T. Ferenbach, T. Aristotelous, I. Hopkins-Navratilova, M. Trost and D.M.F. van Aalten, "A mutant O-GlcNAcase enriches Drosophila developmental regulators", Nature Chem.Biol. (2017), 13, 882-887.

M. Gundogdu, S. Llabrés, A. Gorelik, A.T. Ferenbach, U. Zachariae and D.M.F. van Aalten, "The O-GlcNAc transferase intellectual disability mutation L254F distorts the TPR helix", Cell Chem.Biol. (2018), 25, 513-518.

V.M. Pravata, V. Muha, M. Gundogdu, A.T. Ferenbach, P. Kakade, V. Vandadi, A.C. Wilmes, V.S. Borodkin, S. Joss, M.P. Stavridis and D.M.F. van Aalten, "O-GlcNAc transferase catalytic deficiency in twins with X-linked intellectual disability", Proc.Natl.Acad.Sci.USA, (2019), 116, 14961-14970. 

How good is research at University of Dundee in Biological Sciences?

FTE Category A staff submitted: 73.20

Research output data provided by the Research Excellence Framework (REF)

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