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China Scholarship Council - Investigating the impact of mRNA cap regulation

  • Full or part time
    Prof V Cowling
    Prof T A Owen-hughes
  • Application Deadline
    Wednesday, January 15, 2020
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

The School of Life Sciences at the University of Dundee, joint with the China Scholarship Council (CSC), is proud to be able to offer a scholarship programme for postgraduate research students. The scholarship covers all tuition fees and research fees and provides living expenses and one return flight ticket to successful candidates. There are up to 5 scholarships of 4 years duration available.

Project Description

We investigate the regulation and function of the mRNA cap, a modification of RNA essential for gene expression which integrates transcript processing and translation. We are beginning to understand how oncogenes and signalling pathways can regulate gene expression via regulation of mRNA capping enzymes. Signalling pathways which modify the mRNA capping enzymes have the potential to change the gene expression landscape, thus causing changes in cell physiology.
Our research takes a comprehensive approach including biochemistry, cell biology (immunology and stem cell biology), molecular biology and mass spectrometry, taking advantage of the latest technologies and vast expertise available at the college of life sciences. We collaborate with the Dundee Drug Discovery Unit to explore the therapeutic potential of inhibiting mRNA cap formation in cancers.

Potential projects include
1. Investigating mRNA cap regulation and function in embryonic stem cells. The student will investigate how mRNA cap formation is regulated by developmental cues in embryonic stem cells, and how this process reshapes gene expression profiles and determines cell fate.

2. Investigating mRNA cap regulation and function in T lymphocytes.
The student will investigate how mRNA cap formation is regulated during T cell development and activation, and the impact that this has on gene expression and immune function.

Funding Notes

In order to be eligible for these awards applicants must:

Be a Chinese national
Meet the requirements of the CSC – please see their website
Hold an unconditional offer to study for a PhD at the University of Dundee and meet our English language requirements
Have completed bachelors or masters degree before the agreed start of PhD study.

References

http://www.cell.com/cell-reports/fulltext/S2211-1247(16)30858-0

http://www.cell.com/molecular-cell/fulltext/S1097-2765(16)00092-7

http://gre.dundee.ac.uk/staff/victoria-cowling/

How good is research at University of Dundee in Biological Sciences?

FTE Category A staff submitted: 73.20

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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