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China Scholarship Council PhD Programme: Mode of Action of novel trypanosides

  • Full or part time
  • Application Deadline
    Monday, February 11, 2019
  • Awaiting Funding Decision/Possible External Funding
    Awaiting Funding Decision/Possible External Funding

About This PhD Project

Project Description

Development of new drugs against parasitic diseases is a major need. We are studying a novel class of boron-containing drugs that have action against trypanosomatids, and for which we have evidence of multiple modes of action and activation. The project will involve the use of genetic screens and followup of identified genes that are required for sensitivity towards a panel of drugs, with a view to understanding the mechanisms responsible for specificity, activation and resistant. Work will initially focus on the African trypanosome, but will extend to additional parasites including Leishmania as the work progresses. Excellent support is offered in collaboration with our mode of action team and colleagues within the DDU.

See fieldlab.org for the lab website and the following articles for recent work in this area.

References

Steketee, P.C., Vincent, I.M., Achcar, F., Giordani, F., Kim, D-H., Creek, D.J., Freund, Y., Jacobs, R., Rattigan, K., Horn, D., Field, M.C., MacLeod, A., and Barrett, M.P. (2018) ’Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei.’ PLOS Neglected Tropical Diseases 12(5): e0006450

Wall, R,J., Rico, E., Lukac, I., Zuccotto, F., Elg, S., Gilbert, I.H., Freund, Y., Alley, M.R.K., Field, M.C., Wyllie, S., and Horn, D., (2018) 'The clinical and veterinary trypanocidal oxaboroles target CPSF3.' Proceedings of the National Academy of Sciences (USA) (in the press)

Zhang, N., Zoltner, M., Ka-Fai Leung, K-F., Scullion, P.,. Hutchinson, S., del Pino, R.C., Vincent, I., Zhang, Y-K., Freund, Y.R., Alley, M.R.K., Jacobs, R.T., Read, K.D., Barrett, M.P., Horn, D., and Field, M.C., (2018) ‘Activation and mechanisms of resistance to phenoxyborole class trypanosides.’ PLoS Pathogens 14 e1006850

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