China Scholarship Council PhD Programme: Mode of Action of novel trypanosides at University of Dundee on FindAPhD.com

This project is no longer listed on FindAPhD.com and may not be available.

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Prof M Field No more applications being accepted Awaiting Funding Decision/Possible External Funding

About the Project

Development of new drugs against parasitic diseases is a major need. We are studying a novel class of boron-containing drugs that have action against trypanosomatids, and for which we have evidence of multiple modes of action and activation. The project will involve the use of genetic screens and followup of identified genes that are required for sensitivity towards a panel of drugs, with a view to understanding the mechanisms responsible for specificity, activation and resistant. Work will initially focus on the African trypanosome, but will extend to additional parasites including Leishmania as the work progresses. Excellent support is offered in collaboration with our mode of action team and colleagues within the DDU.

See fieldlab.org for the lab website and the following articles for recent work in this area.

References

Steketee, P.C., Vincent, I.M., Achcar, F., Giordani, F., Kim, D-H., Creek, D.J., Freund, Y., Jacobs, R., Rattigan, K., Horn, D., Field, M.C., MacLeod, A., and Barrett, M.P. (2018) ’Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei.’ PLOS Neglected Tropical Diseases 12(5): e0006450

Wall, R,J., Rico, E., Lukac, I., Zuccotto, F., Elg, S., Gilbert, I.H., Freund, Y., Alley, M.R.K., Field, M.C., Wyllie, S., and Horn, D., (2018) 'The clinical and veterinary trypanocidal oxaboroles target CPSF3.' Proceedings of the National Academy of Sciences (USA) (in the press)

Zhang, N., Zoltner, M., Ka-Fai Leung, K-F., Scullion, P.,. Hutchinson, S., del Pino, R.C., Vincent, I., Zhang, Y-K., Freund, Y.R., Alley, M.R.K., Jacobs, R.T., Read, K.D., Barrett, M.P., Horn, D., and Field, M.C., (2018) ‘Activation and mechanisms of resistance to phenoxyborole class trypanosides.’ PLoS Pathogens 14 e1006850

Where will I study?

University of Dundee

The University of Dundee brings together some of the best researchers in the world, developing ideas that positively impact the physical, social and psychological wellbeing of people and their communities, the economy, and the environment.

China Scholarship Council PhD Programme: Mode of Action of novel trypanosides

University of Dundee School of Life Sciences

This project is no longer listed on FindAPhD.com and may not be available.

About the Project

References

Where will I study?

University of Dundee

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