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China Scholarship Council - Regulation of protein degradation by ubiquitylation


Project Description

The School of Life Sciences at the University of Dundee, joint with the China Scholarship Council (CSC), is proud to be able to offer a scholarship programme for postgraduate research students. The scholarship covers all tuition fees and research fees and provides living expenses and one return flight ticket to successful candidates. There are up to 5 scholarships of 4 years duration available.

Project Description

Ubiquitin signalling, which involves the posttranslational modification (PTM) of proteins with ubiquitin, regulates almost every aspect of eukaryotic biology. This versatility is possible because proteins can be modified with different types of ubiquitin codes resulting in distinct functional outcomes. An indispensable role for ubiquitylation is to serve as a signal for the degradation of misfolded and damaged proteins. In addition to degradation, ubiquitin modifications can serve as distinct signals to facilitate intracellular communication. The cellular machinery therefore has to read the different ubiquitin codes in order to ensure that the appropriate response is produced. Further, these codes have to be erased once the functional outcome is produced, a process carried out by a class of enzymes known as Deubiquitinases. In the lab we study these processes, using a range of techniques including biochemical approaches, proteomics, structural biology and mouse models to elucidate new layers of control in protein degradation. This research is fundamental to our understanding of cell biology in health, and is important, as failures in protein degradation underly many diseases especially age-related diseases such as Alzheimer’s and Parkinson’s disease.

We are looking for an enthusiastic student to join the group to study how protein degradation is regulated by the ubiquitin system. Your PhD will build upon tools, reagents and models we have recently established in the lab. Working on an independent project, you will have the opportunity to learn and apply different approaches ranging from biochemistry, cell biology, genetic screens and state-of-the-art proteomics methods to understand at the molecular level how aberrant proteins are degraded, the ubiquitin signals involved, how they are decoded and how this process is regulated. This project will provide the opportunity to improve our understanding of one of the most fundamental processes in the cell.

Funding Notes

In order to be eligible for these awards applicants must:

Be a Chinese national
Meet the requirements of the CSC – please see their website
Hold an unconditional offer to study for a PhD at the University of Dundee and meet our English language requirements
Have completed bachelors or masters degree before the agreed start of PhD study.

References

1. Kwasna D, et al. (2018) “Discovery and characterization of ZUFSP, a novel DUB class important for genome stability”. Molecular Cell. 70(1):150-164.
2. Kristariyanto YA, et al. “A single MIU motif of MINDY-1 recognizes K48-linked polyubiquitin chains”. EMBO Reports 18 (3): 392-402
3. Kristariyanto YA, et al. (2015) “K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of K29 polyubiquitin”. Molecular Cell 58(1): 83-94

How good is research at University of Dundee in Biological Sciences?

FTE Category A staff submitted: 73.20

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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