Chromatin Architecture, Enhancer Structure and Congenital Abnormalities
This is one of several projects available on an MRC funded 4-year multi-disciplinary PhD programme in Human Genetics, Genomics and Disease at the MRC Human Genetics Unit (HGU), part of the Institute of Genetics and Molecular Medicine (IGMM) at the University of Edinburgh.
Mutations which affect gene regulation are becoming increasingly recognised as important disease causing variations. A number of mechanisms perturb enhancer activity to generate abnormal phenotypes and we propose to investigate novel regulatory mechanisms that cause disease. Our model system for understanding abnormal gene regulation is the sonic hedgehog (Shh) gene, a signalling molecule that controls early development, and requires a genomic region of one million basepairs of DNA to regulate precise gene expression. To further elucidate mechanism, we will use CRISPR/Cas9 to engineer the chromosomal landscape for molecular analysis and to further develop imaging techniques to analyse chromatin structure.
For further information on how to apply for this project, please visit: https://www.ed.ac.uk/mrc-human-genetics-unit/graduate-research-and-training/mrc-four-year-phd-programme-human-genetics-genomic
For full funding (fees and stipend) students must be UK or EU citizens who have been resident in the UK for 3 years prior to commencement.
However, EU students with quantitative or multidisciplinary skills are eligible for full funding.