This is one of several projects available on an MRC funded 4-year multi-disciplinary PhD programme in Human Genetics, Genomics and Disease at the MRC Human Genetics Unit (HGU), part of the Institute of Genetics and Molecular Medicine (IGMM) at the University of Edinburgh.
In mammals, genetic information is passed from generation to generation by germ cells. Errors in chromosome segregation are relatively common in human oocytes, particularly during meiosis, and cause genetic diseases such as Down syndrome in the next generation. These errors occur more frequently in oocytes from older mothers, but the reason for this age-dependent effect is not completely understood. You will use embryonic stem cells to investigate how pathways influencing chromosome segregation in mouse oocytes impact on chromosome-associated proteins. You will also use gene editing in mice to manipulate these pathways and exacerbate or ameliorate chromosome mis-segregation in meiotic oocytes.