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Circadian control of secretory pathway function

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

About This PhD Project

Project Description

Cells are the fundamental unit of life. Our aim is to understand cell function in the context of membrane and cytoskeleton dynamics. A key focus is the secretion of procollagen and its assembly into a functional extracellular matrix1. Recent data from our collaborators has shown that the circadian rhythm impacts directly on secretory pathway function, notably to control assembly of the collagen matrix 2. We are keen to develop projects in this area to define the way in which the circadian rhythm controls secretory pathway function.
The lab specialises in the analysis of membrane traffic in mammalian cells using advanced light microscopy techniques. Our work includes developing imaging technologies and integrating model systems including 3D cultures and zebrafish to develop our research. The lab itself is using high-resolution light microscopy of living cells, notably live cell imaging, in 3D over time, to examine the organisation and function of the mammalian secretory pathway both in healthy cells as well as in disease states.

For further information see:
Web: https://stephenslab.blogs.bristol.ac.uk/
Twitter: @David_S_Bristol

References

1. McCaughey, J., Stevenson, N.L., Cross, S. & Stephens, D.J. ER-to-Golgi trafficking of procollagen in the absence of large carriers. J. Cell Biol. 218, 929-948 (2019).

2. Yeung, C.-Y.C. et al. Circadian Clock Regulation of the Secretory Pathway. bioRxiv (2018).

Related Subjects

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