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Circadian Rhythms and Aging

  • Full or part time
  • Application Deadline
    Thursday, March 28, 2019
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

About This PhD Project

Project Description

Neuroscience PhD Studentship

Circadian Rhythms and Aging

University of Kent –Medway School of Pharmacy

A fully funded PhD position for 3 years is available starting in October 2019 within the School of Pharmacy, University of Kent. The research aims of this project are to explore the impact of Aging on the mammalian circadian clock.

The environmental day/night cycle is an essential component of life; where throughout the evolutionary chain, organisms have used this signal as a timing cue to which they regulate/ synchronise their 24 hour (circadian) biological activity. Aging of the physiological components that govern and maintain circadian rhythms in mammals result in disruption to the clock leading to problems in sleep, cognition and social function. This studentship will focus on unravelling the mechanism by which aging affects the mammalian circadian clock. The project will utilise both in vivo and in vitro techniques, ranging from behavioural experimentation through to molecular methodologies.

Applicants should hold a minimum upper-second class honours degree (or equivalent) in a relevant subject discipline such as neuroscience, physiology, pharmacology, or any other life science related subject area. Prior experience in either circadian biology would be an advantage, but not essential. Annual stipend is set to £15,009 in the first instance.

Informal enquires should be made to Dr. Gurprit Lall (; Tel: +44 (0)1634 202964). Applications should be in the form of a full C.V. and covering letter either emailed or sent to Dr. Gurprit Lall. Medway School of Pharmacy, University of Kent, Anson Building, Central Avenue, Chatham, Kent, ME4 4TB. Closing date for all applicants is 28th March 2019.


References

Steponenaite, A, Biello, SM and Lall, GS (2018). Aging clocks: disrupted circadian rhythms. Aging, 10:3065-3066.

Biello, SM, Bonsall, DM, Atkinson, LA, Molyneux, P, Harrington, ME and Lall, GS (2018). Alterations in glutamatergic signalling contribute to the decline of circadian photoentrainment in aged mice. Neurobiology of Aging, 66:75-84.

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