FindA University Ltd Featured PhD Programmes
FindA University Ltd Featured PhD Programmes
FindA University Ltd Featured PhD Programmes

Clinical pharmacology studies of benzathine penicillin and benzylpenicillin

Faculty of Health Sciences

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Prof K Batty No more applications being accepted Funded PhD Project (Students Worldwide)

About the Project

Rheumatic heart disease (RHD) affects more than 33 million people globally and leads to >300,000 deaths per year, almost all at a prematurely young age, and in settings of poverty. There is renewed focus on RHD, highlighted by adoption of the Global Resolution on Acute Rheumatic Fever (ARF) and RHD by the World Health Assembly in 2018. At present, secondary prophylaxis in the form of 3- to 4-weekly intramuscular (IM) benzathine penicillin injections are the cornerstone of RHD control, and the only proven approach that is both therapeutically and cost-effective. The overall management is limited by poor adherence to painful IM injections given on a monthly basis. Consequently, the majority of people with ARF or RHD do not receive adequate secondary prophylaxis.

Against this background, the proposed research program will comprise part of a suite of clinical studies, including an NHMRC-funded project [#1187743] investigating the effect of penicillin in a controlled human infection for Streptococcus pyogenes, and a study of subcutaneous infusions of penicillin in RHD. Using a combination of analytical and pharmacokinetic modelling methods, this research will evaluate penicillin for novel clinical and research applications, to inform further clinical studies in Australian settings and international collaborators’ institutions

Funding Notes

Total value of the annual scholarships (stipend and fees) is approx. $60,000 - $70,000 p.a.

Curtin PhD Stipends are valued at $28,092 p.a. for up to a maximum of 3.5 years.

For a successful international student, PhD tuition fees offsets between 75% – 100% will apply.

Successful recipients of this scholarship will receive scholarship benefits including:
- Tuition Fee Offset (up to 4 years)
- Stipend payments whilst located onshore in Australia
- Research Support Funds
- Mobility Funds

Successful applicants must meet the Curtin University entry requirements for admission into a Higher Degree by Research course.

Students who commence studies offshore will receive a set lump sum payment in lieu of the stipend upon completion of Milestone 1. After Milestone 1 the stipend will commence for up to 3 years minus any prior consumed EFTSL.
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